Harshul Patidar Assistant Professor, Department of Pathology, GMC, Khandwa & Consultant Pathologist (Sampurna Sodani Diagnostic Clinic, Khandwa Branch), India
Uditkumar Agrawal Associate Professor, Department of Biochemistry, GMC, Khandwa, India
Sadhna Sodani Associate Professor, Department of Microbiology, MGMMC, Indore Hon.Director, Sampurna Sodani Diagnostic Clinic, Indore, Madhya Pradesh, India
Shikha Agrawal Assistant Professor, Department of Anesthesia, GMC, Khandwa, India
Ranjana Hawaldar Head Pathologist, Sampurna Sodani Diagnostic Clinic, Indore, Madhya Pradesh, India
Keywords: Type 2 diabetes mellitus, Mean platelet volume, HbA1c.
ABSTRACT
Background: Type 2 diabetes mellitus (T2DM) patients have a higher risk of developing complications, which lead to decrease in the quality of life and increase in morbidity. Platelet indices have been available in the laboratory routine using blood cell counters for several years. P latelets (PLT) are directly or indirectly involve in the processes of chronic complications in T2DM. Beside serving as a marker of platelet activation, mean platelet volume (MPV) is also considered as an inflammatory indice. Increased activity has been noted in Platelets with increased volume when compared to smaller ones, thus highlighting the utility of Mean platelet volume as a marker of platelet activity.
Aim: To evaluate MPV in patients with type II DM in comparison with a healthy control group . Materials and Methods: In total, 50 diabetic patients along with age and sex matched non-diabetic controls were studied. A detailed history was taken regarding duration of diabetes, medication, past history of stroke and hypertension. Platelet indices, fasting blood glucose, Post prandial blood glucose and HbA1C were obtained from venous blood samples. All parameters were then subjected to statistical analysis using SPSS 20.0. Data was expressed as mean +/- standard deviation. A p-value <0.05 was considered statistically significant. Results: Platelet indices, namely MPV, PCT were significantly higher in diabetic individuals. Platelet dysfunction also showed a positive association with HbA1C. Conclusion: Changes in platelet indices were found to be statistically associated with diabetes.
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